Abstract
The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Cell Differentiation / genetics
-
Cell Division / genetics
-
Cell Size / genetics
-
Hamartoma Syndrome, Multiple / genetics
-
Humans
-
Neurons / cytology*
-
PTEN Phosphohydrolase
-
Phosphoric Monoester Hydrolases / genetics*
-
Phosphoric Monoester Hydrolases / metabolism*
-
Tumor Suppressor Proteins / genetics*
-
Tumor Suppressor Proteins / metabolism*
Substances
-
Tumor Suppressor Proteins
-
Phosphoric Monoester Hydrolases
-
PTEN Phosphohydrolase
-
PTEN protein, human